MHRA Approves the First Needle-Free Adrenaline Nasal Spray for Anaphylaxis

The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a major new development in the treatment of severe allergic reactions. For the first time in the UK, a needle-free adrenaline nasal spray has been authorised for emergency use in cases of anaphylaxis — a sudden, severe, and potentially life-threatening allergic reaction.

A New Alternative to Traditional Adrenaline Auto-Injectors

Until now, adrenaline for anaphylaxis has always been delivered by injection, typically using auto-injectors such as the EpiPen. These devices are highly effective, but for some people — particularly those with a strong fear of needles or who struggle to administer an injection during a crisis — they can present challenges.

The newly approved nasal spray provides a needle-free, single-dose, ready-to-use alternative. Administered through the nostril, the spray delivers adrenaline rapidly into the bloodstream via the nasal mucosa.

Who Can Use It?

The spray is approved for:

• Adults
• Children weighing 30 kg or more (typically around 10 years old and above)

Nasal Spray vs Adrenaline Auto-Injectors

The MHRA has emphasised that this new nasal spray does not replace traditional adrenaline auto-injectors. Adrenaline pens remain vital, effective, and life-saving tools. Anyone who currently carries an auto-injector must continue to do so.

Instead, the nasal spray adds an additional safe and effective option — particularly helpful for situations where injections are difficult, delayed, or distressing.

Key Points to Know

• The spray can be used even if the casualty has a blocked or congested nose.
• People at risk of anaphylaxis should always carry two doses, regardless of whether they use a spray or an auto-injector.
• Family members, friends, colleagues, and teachers should know how to recognise anaphylaxis and administer treatment.

MHRA Approval and Safety

The decision follows a detailed review of clinical evidence showing that the nasal spray delivers adrenaline safely and effectively. This innovation marks an important advancement, making emergency treatment more accessible and user-friendly for people living with severe allergies.

What to Do in Suspected Anaphylaxis

Regardless of the type of adrenaline used, the priorities remain unchanged:

• Recognise the symptoms quickly
• Administer adrenaline without delay
• Call 999 immediately
• Continue to monitor and support the casualty until emergency help arrives

This new needle-free adrenaline spray represents a significant step forward in emergency allergy treatment — offering greater choice, improved accessibility, and a potentially easier way to deliver life-saving care when every second counts.